heterogeneous nuclear ribonucleoprotein D-like; hnRNP D-like; hnRNP DL; AU-rich element RNA-binding factor; JKT41-binding protein; protein laAUF1 (HNRNPDL, HNRPDL, JKTBP)
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Function
- transcriptional regulator
- promotes transcription repression
- promotes transcription activation in differentiated myotubes
- binds to double- & single-stranded DNA sequences
- binds to transcription suppressor CATR sequence of the COX5B promoter
- binds with high affinity to RNA molecules that contain AU-rich elements found within the 3'-UTR of many proto-oncogenes & cytokine mRNAs
- binds both to nuclear & cytoplasmic poly(A) mRNAs
- poly(G) & poly(A), but not to poly(U) or poly(C) RNA homopolymers
- binds to the 5'-ACUAGC-3' RNA consensus sequence
- interacts with ZNF148, TNPO1
Structure
- dimethylation of Arg-408 is probably of asymmetric type
- contains 2 RRM domain (RNA recognition motif)
Compartment
Alternative splicing
named isoforms=3
Expression
- expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon & leukocytes
- up-regulated by 12-O-tetradecanoylphorbol 13-acetate in macrophages & retinoic acid in granulocytes
- down-regulated by interleukin-4
Pathology
- expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma, urinary bladder carcinoma cells