zinc finger protein 148; zinc finger DNA-binding protein 89; transcription factor ZBP-89 (ZNF148, ZBP89)

Function

• role in transcriptional regulation
• represses the transcription of a number of genes including gastrin, stromelysin & enolase
• binds to the G-rich box in the enhancer region of these genes
• interacts with HNRPDL

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 4 C2H2-type Zn+2 fingers

Compartment

nucleus

More general terms

• transcriptional silencer (transcriptional repressor)
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7707
• OMIM: https://mirror.omim.org/entry/601897
• UniProt: http://www.uniprot.org/uniprot/Q9UQR1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7707