heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1 (HNRNPA2B1, HNRPA2B1)

Function

• role with pre-mRNA processing
• forms complexes (ribonucleosomes) with at least 20 other different hnRNP & heterogeneous nuclear RNA in the nucleous
• identified in the spliceosome C complex

Structure

contains 2 RRM domain (RNA recognition motif)s

Compartment

• nucleus, nucleoplasm, cytoplasm
• component of ribonucleosomes
• predominantly nucleoplasmic; however, isoform A2 is also found in the cytoplasm of cells in some tissues
• not found in the nucleolus

Alternative splicing

named isoforms=2; B1, A2

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• RNA-binding protein
• phosphoprotein

Component of

• spliceosome C complex

Database

• UniProt: http://www.uniprot.org/uniprot/P22626.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3181
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3181
• OMIM: https://mirror.omim.org/entry/600124