heterogeneous nuclear ribonucleoprotein L-like; hnRNPLL; stromal RNA-regulating factor (HNRNPLL, HNRPLL, SRRF, BLOCK24)

Function

• RNA-binding protein
• functions as regulator ofalternative splicing for multiple target mRNAs, including PTPRC/CD45 & STAT5A
• required for alternative splicing of PTPRC
• interacts with HNRNPL

Structure

contains 3 RRM domains (RNA recognition motif)

Alternative splicing

named isoforms=4

Expression

• widely expressed
• detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney, lung
• up-regulated in stimulated T-cells

More general terms

• RNA-binding protein
• heterogeneous nuclear ribonucleoprotein (hnRNP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=92906
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:92906
• OMIM: https://mirror.omim.org/entry/611208
• UniProt: http://www.uniprot.org/uniprot/Q8WVV9.html