CD45 (leukocyte common antigen T200 or protein tyrosine phosphatase, receptor type, C polypeptide)
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Function
- required for T & B cell antigen receptor-mediated activation
Alternative splicing
at least 8 isoforms
Expression
- present on all leukocytes
- different isoforms are expressed in different subsets of hematopoietic cells:
- CD45RA: naive/resting T cells, medullary thymocytes
- expressed in hematopoietic cells, stronger staining in lymphocytes
- expressed in red blood cells, non-hematopoietic cells
- in the CNS, CD45 is a marker of microglia[4]
Pathology
- lymphoplasmacytic lymphoma, lymphoblastic lymphoma, anaplastic lymphoma, multiple myeloma
- Reed-Sternberg cells stain negatively with antibody
More general terms
More specific terms
References
- ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- ↑ Webb DS et al LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release. Science 249:1295 1990 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/1697984
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ 4.0 4.1 Wilcock et al, American Aging Association, 33rd Annual meeting, June 4-7, 2004