heterogeneous nuclear ribonucleoprotein K; hnRNP K; transformation up-regulated nuclear protein; TUNP (HNRNPK, HNRPK)

Function

• major pre-mRNA-binding protein
• binds tenaciously to poly(C) sequences
• likely to play a role in nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences
• can also bind poly(C) single-stranded DNA
• Arg-296 & Arg-299 are dimethylated, probably to asymmetric dimethylarginine
• interacts with RBM42 & ZIK1 (putative)
• identified in the spliceosome C complex
• interacts with HCV core protein
• interacts with ASFV p30 protein

Structure

• contains 3 KH domains
• mass=50976.25 by mass spec

Compartment

• cytoplasm. nucleus, nucleoplasm

Alternative splicing

named isoforms=3

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• DNA-binding protein
• RNA-binding protein
• phosphoprotein

Component of

• spliceosome C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3190
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3190
• OMIM: https://mirror.omim.org/entry/600712
• UniProt: http://www.uniprot.org/uniprot/P61978.html