heterogeneous nuclear ribonucleoprotein M; hnRNP M (HNRNPM, HNRPM, NAGR1)

Function

• pre-mRNA binding protein in vivo
• binds avidly to poly(G) & poly(U) RNA homopolymers in vitro
• role in RNA splicing
• acts as a receptor for carcinoembryonic antigen in Kupffer cells
• may initiate a series of signaling events leading to Tyr phosphorylation of proteins & induction of IL-1 alpha, IL-6, IL-10 & TNF-alpha cytokines
• sumoylated
• identified in the spliceosome C complex

Structure

contains 3 RRM domain (RNA recognition motif)s

Compartment

nucleus, nucleolus

Alternative splicing

named isoforms=3

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• RNA-binding protein
• phosphoprotein

Component of

• spliceosome C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4670
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4670
• OMIM: https://mirror.omim.org/entry/160994
• UniProt: http://www.uniprot.org/uniprot/P52272.html