dexamethasone/tobramycin (Tobradex)

Introduction

Tobramycin/Dexamethasone.

Indications

• topical treatment of infection & inflammation due to E coli, H influenzae, M lacunata, Neisseria, Proteus, Pseudomonas, S aureus, S epidermidis, Serratia,
• decrease inflammation & complicating bacterial infections associated with Herpes zoster
• inflammation & infection associated with
  • corneal abrasion
  • corneal perforation

Contraindications

pregnancy-category C

safety in lactation ?

Dosage

• ointment: BID-QID
• solution: 1 drop every 1-6 hours

Adverse effects

• increased lacrimation
• itching
• edema of the eyelids
• conjunctival erythema

Mechanism of action

• binds bacterial 30S ribosomal subunit
• inhibits bacterial protein synthesis
• disrupts bacterial cell membrane
• corticosteroid

More general terms

• antibiotic-glucocorticoid combination

Components

• dexamethasone (Decadron, Maxidex, AK-Dex, Ozurdex)
• tobramycin (Nebcin, Tobrex)