aripiprazole (Abilify)

From Aaushi
Jump to navigation Jump to search

Indications

Dosage

Tabs: 2,5,10,15,20, 30 mg

Injection: for IM injection[11]

Pharmacokinetics

Adverse effects

* change aripiprazole to lamotrigine (NEJM)[16]

Mechanism of action

Notes

  • generic FDA-approced April 2015
  • aripiprazole wth an ingestible sensor embedded (Abilify MyCite) digitally records whether & when the medication is taken FDA-approved Nov 2017[15]
    • ingestible sensor transmits a message to a patch worn by the patient
    • the patch then sends the information to a mobile device[15]
    • not been shown to improve patient compliance

More general terms

More specific terms

References

  1. Prescriber's Letter 9(12):69 2002
  2. 2.0 2.1 2.2 Prescriber's Letter 10(11):62 2003
  3. 3.0 3.1 3.2 Prescriber's Letter 12(9): 2005 Role of atypical antipsychotics in treating patients with Schizophrenia: Are they better than older agents? Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=211107&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. 4.0 4.1 4.2 Prescriber's Letter 15(1): 2008 Treatment-Resistant Depression Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240103&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. http://www.fda.gov/cder/consumerinfo/druginfo/abilify.htm
  6. http://www.abilify.com
  7. Department of Veterans Affairs, VA National Formulary
    restricted to psychiatry
  8. 8.0 8.1 Correll CU et al Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents JAMA. 2009;302(16):1765-1773 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19861668 <Internet> http://jama.ama-assn.org/cgi/content/short/302/16/1765
    Varley CK & McClellan J Implications of Marked Weight Gain Associated With Atypical Antipsychotic Medications in Children and Adolescents JAMA. 2009;302(16):1811-1812 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19861677 <Internet> http://jama.ama-assn.org/cgi/content/short/302/16/1811
  9. Prescriber's Letter 17(1): 2010 Atypical Antipsychotics in Kids Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260102&pb=PRL (subscription needed) http://www.prescribersletter.com
  10. 10.0 10.1 Deprecated Reference
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
  12. FDA News Release. April 28, 2015 FDA approves first generic Abilify to treat mental illnesses. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm444862.htm
  13. 13.0 13.1 Lenze EJ et al Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo- controlled trial. Lancet. Published Online: 27 September 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26423182 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2900308-6/abstract
    Thomas A, O'Brien JT Management of late-life depression: a major leap forward. Lancet. Published Online: 27 September 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26423179 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2900304-9/abstract
  14. 14.0 14.1 FDA Safety Watch. May 3, 2016 Aripiprazole (Abilify, Abilify Maintena, Aristada): Drug Safety Communication - FDA Warns About New Impulse-control Problems. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm498823.htm
  15. 15.0 15.1 15.2 Brooks M FDA Clears Drug With Ingestible Digital Tracker. Medscape - Nov 14, 2017. https://www.medscape.com/viewarticle/888586
  16. 16.0 16.1 16.2 16.3 16.4 16.5 NEJM Knowledge+ Neurology
  17. HIGHLIGHTS OF PRESCRIBING INFORMATION ABILIFY<TM> (aripiprazole) Tablets https://www.otsuka-us.com/sites/g/files/qhldwo3916/files/media/static/Abilify-PI.pdf

Database