orphenadrine (Norflex)

Introduction

Orphenadrine. Tradename: Norflex.

Indications

• muscle spasm associated with acute painful musculoskeletal conditions

Dosage

• 60 mg IV/IM BID
• 100 mg PO BID

Tabs: 100 mg.

Injection: 30 mg/mL (2 mL)

Adverse effects

• common (> 10%)
  • drowsiness, dizziness, blurred vision B2) less common (1-10%)
  • flushing of the face, tachycardia, syncope, rash, nausea/vomiting, constipation, decreased urination, weakness, nystagmus, increased intraocular pressure, nasal congestion
• uncommon (< 1%)
  • hallucinations, aplastic anemia

• drug adverse effects of H1 receptor antagonists

Laboratory

• orphenadrine in serum/plasma
• methods: GLC

More general terms

• H1 receptor antagonist (antihistamine)
• skeletal muscle relaxant (tranquilizer)

Component of

• acetaminophen/orphenadrine
• aspirin/caffeine/citrate/orphenadrine
• aspirin/caffeine/orphenadrine (Norgesic)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4601
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=58823
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=657244
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9568