skeletal muscle relaxant (tranquilizer)
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Indications
- spasticity, muscle spasms
- may be useful for
- painful muscle spasms
- muscle cramps
- neck pain
Contraindications
- low back pain
- of no benefit added to ibuprofen in treatment of low back pain[3]
- fibromyalgia
- headaches
Adverse effects
- risk of falls: baclofen, cyclobenzaprine > tizanidine
- risk of fracture: baclofen, cyclobenzaprine = tizanidine[2]
More general terms
More specific terms
- alcuronium
- baclofen (Lioresal)
- beta-erythroidine
- carisoprodol (Soma, Rela)
- chlormezanone (Trancopal)
- chlorzoxazone (Parafon, Parafon-Forte)
- cyclobenzaprine (Flexeril)
- dantrolene (Dantrium)
- diazepam (Vallium, Diastat)
- eperisone (Myonal, Epry)
- gallamine (Pirolakson, Flaxedil)
- metaxalone (Skelaxin)
- methocarbamol (Robaxin)
- metocurine; dimethyl tubocurarine (Metubine Iodide)
- orphenadrine (Norflex)
- quinine (Quinamm, Aflukin, Chinimetten, Qualaquin)
- tizanidine (Zanaflex)
References
- ↑ Chou R, Peterson K, Helfand M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage. 2004 Aug;28(2):140-75. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15276195
- ↑ 2.0 2.1 Hwang YJ, Chang AR, Brotman DJ, Inker LA, Grams ME, Shin JI. Baclofen and the risk of fall and fracture in older adults: A real-world cohort study. J Am Geriatr Soc. 2023 Nov 7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37933734 https://agsjournals.onlinelibrary.wiley.com/doi/abs/10.1111/jgs.18665
- ↑ 3.0 3.1 Friedman BW, Irizarry E, Solorzano C et al. A randomized, placebo-controlled trial of ibuprofen plus metaxalone, tizanidine, or baclofen for acute low back pain. Ann Emerg Med 2019 Apr 5; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30955985 https://www.annemergmed.com/article/S0196-0644(19)30139-8/fulltext
- ↑ Talwadekar M Muscle Relaxants for Chronic Pain: Where Is the Greatest Evidence? Medscape. September 20, 2024 https://www.medscape.com/viewarticle/muscle-relaxants-chronic-pain-where-greatest-evidence-2024a1000h3w