desvenlafaxine; norvenlafaxine; N-desmethylvenlafaxine (Pristiq)
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Introduction
Tradename: Pristiq (FDA approved 2008)
Indications
- depression (FDA approved use)
- hot flashes
- fibromyalgia
- neuropathic pain
- generalized anxiety disorder[6]
- panic disorder,
- social phobia[6]
Dosage
- start 50 mg PO QD; larger doses do not improve efficacy
- Maximum dose: 400 mg QD[5]
- can be started at therapeutic dose (50 mg QD)
- does not require lead-in dose as dose venlafaxine
Tabs: 50, 100 mg
Pharmacokinetics
- see venlafaxine (not metabolized by liver)
Adverse effects
- similar to venlafaxine
- dizziness, nausea, headache most common
- hypertension most common serious side effect (4%)
- other: xerostomia, sexual dysfunction, insomnia[3]
Laboratory
Mechanism of action
- active metabolite of venlafaxine
- inibits reuptake of serotonin & norepinephrine
More general terms
References
- ↑ Prescriber's Letter 14(2): 2007 Follow-on Drugs: Therapeutic benefit of economic burden? Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=230201&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Speroff L et al, Efficacy and tolerability of desvenlafaxine succinate treatment for menopausal vasomotor symptoms: A randomized controlled trial. Obstet Gynecol 2008, 111:77 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18165395
- ↑ 3.0 3.1 Prescriber's Letter 15(5): 2008 Comparison of Commonly Used Antidepressants Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240509&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Prescriber's Letter 16(2): 2009 Comparison of Venlafaxine and Desvenlafaxine (Pristiq) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250202&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 5.0 5.1 Prescriber's Letter 17(8): 2010 CHART: Comparison of Venlafaxine and Desvenlafaxine CHART: State Regulations on Generic Substitution Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260802&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 6.0 6.1 6.2 Deprecated Reference