vardenafil (Levitra, Staxyn)

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Introduction

Tradename: Levitra. New agent from Bayer. (2003)

Indications

Contraindications

Dosage

  • 5-20 mg 25-60 minutes before intercourse
  • start 10 mg & adjust to need

Tabs: 5, 10, 20 mg. (shelf-life 3 years)

Dosage adjustment in renal failure

Pharmacokinetics

elimination via liver

protein binding = 95 %

Adverse effects

Drug interactions

Laboratory

Mechanism of action

* both phosphodiesterase-5 inhibitors & nitric oxide converge on the same pathway; both increase cGMP. Phosphodiesterase-5 inhibitors inhibit hydrolysis of cGMP. Nitric oxide activates guanylate cyclase increasing synthesis of cGMP

More general terms

Additional terms

References

  1. Prescriber's Letter 8(10):57 2001
  2. 2.0 2.1 Prescriber's Letter 10(9):49 2003
  3. 3.0 3.1 Prescriber's Letter 10(11):62 2003
  4. http://www.levitraguide.com
  5. Prescriber's Letter 18(8): 2011 COMMENTARY: New Vardenafil Formulation: Staxyn CHART: Phosphodiesterase 5 (PDE5) Inhibitor Interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270809&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022

Database