phosphodiesterase 5; cGMP-specific phosphodiesterase

Function

hydrolyzes cGMP

Expression

• expressed in high concentrations in the corpus cavernosum

Pharmacology

• PDE5 is the target of sildenafil (Viagra) & other PDE5 inhibitors

More general terms

• cyclic nucleotide phosphodiesterase

More specific terms

• cGMP-specific 3',5'-cyclic phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE (PDE5A)