phentermine (Fastin, Ionamin, Adipex)
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Introduction
Tradenames: Fastin, Ionamin. DEA-controlled substance: class 4.
Indications
- short-term treatment for weight reduction
Contraindications
- glaucoma
- hypertension
- hyperthydoidism
- coronary artery disease
- heart failure
- agitation
- pregnancy
- lactation
Dosage
Tabs: 8, 15, 18.75, 30 mg.
Pharmacokinetics
- metabolized in liver to largely inactive metabolites
- metabolites excreted by the kidney
- 1/2life: 7-24 hours
elimination via kidney
elimination via liver
1/2life = 7-24 hours
Adverse effects
- insomnia
- agitation
- nervousness
- hyperthermia
- hyperventilation
- hypertension
- convulsions Test interferences:
- may cause false positives in immunoassays for amphetamines in urine
- drug adverse effects of analeptics
- drug adverse effects of psychotropic agents
- drug adverse effects of sympathomimetic(s)
Mechanism of action
More general terms
- adrenergic neuron stimulant
- analeptic (CNS stimulant)
- anorexiant (appetite suppressant)
- amine
- aromatic compound
Additional terms
Component of
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
- ↑ Micromedex
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 461