phentermine (Fastin, Ionamin, Adipex)

Introduction

Tradenames: Fastin, Ionamin. DEA-controlled substance: class 4.

Indications

• short-term treatment for weight reduction

Contraindications

• glaucoma
• hypertension
• hyperthydoidism
• coronary artery disease
• heart failure
• agitation
• pregnancy
• lactation

pregnancy category = ?

safety in lactation = ?

Dosage

• start 15-30 mg PO QD
• maximum: 37.5 mg QD

Tabs: 8, 15, 18.75, 30 mg.

Pharmacokinetics

• metabolized in liver to largely inactive metabolites
• metabolites excreted by the kidney
• 1/2life: 7-24 hours

elimination via kidney

elimination via liver

1/2life = 7-24 hours

Adverse effects

• insomnia
• agitation
• nervousness
• hyperthermia
• hyperventilation
• hypertension
• convulsions

• drug adverse effects of analeptics
• drug adverse effects of psychotropic agents
• drug adverse effects of sympathomimetic(s)

Drug interactions

• may cause false positives in immunoassays for amphetamines in urine

Mechanism of action

• CNS stimulants
• appetite suppressant

More general terms

• adrenergic neuron stimulant
• analeptic (CNS stimulant)
• anorexiant (appetite suppressant)
• amine
• aromatic compound

Additional terms

• chlorphentermine (Clorfentermina, Desopimon, Dezopimon, Lucofene)
• mephentermine (Wyamine)

Component of

• fenfluramine/phentermine (fen-phen)
• phentermine/topiramate (Qnexa, Qsymia)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4771
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=70969