maprotiline (Ludiomil)

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Introduction

Tradename: Ludiomil.

Indications

Dosage

Start 25-75 mg PO QHS, max 225 mg/day

Tabs: 25, 50, 75 mg.

Pharmacokinetics

elimination via liver

1/2life = 28 hours

protein binding = 88 %

elimination by hemodialysis = -

elimination by peritoneal dialysis = -

Adverse effects

(increased at > 300 ng/mL)

Drug interactions

Laboratory

Notes

Maprotiline is a secondary amine

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. 2.0 2.1 Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  3. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com

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