norethindrone (Norlutate, Aygestin, Micronor)

Introduction

Tradenames: Norlutate, Aygestin, Micronor Progestin.

Indications

• amenorrhea or abnormal uterine bleeding due to hormonal imbalance
• endometriosis
• oral contraceptive (alone or in combination with estrogens)

Dosage

5-10 mg PO QD PRN

Tablets: (acetate, Norlutate) 5 mg. Oral Contraceptives:

• 0.35 mg QD for 28 days of cycle (28 days)

Tablets: (Micronor) 0.35 mg

Tablets: (acetate, Norlutate) 5 mg.

Adverse effects

• common (> 10%)
  • breakthrough bleeding, spotting, changes in menstrual flow, amenorrhea, pain at site of injection, anorexia, edema, weakness
• less common (1-10%)
  • edema, depression, fever, melasma, chloasma, allergic rash with or without pruritus, cholestatic jaundice,changes in cervical erosion & secretions, weight gain or loss, insomnia, breast tenderness

More general terms

• progestational agent

Component of

• elagolix/estradiol/norethindrone
• estradiol/ethinyl estradiol/norethindrone
• estradiol/ethinyl estradiol/ferrous fumarate/iron/norethindrone
• ethinyl estradiol/norethindrone/ferrous fumarate (Larin Fe)
• estradiol/ethinyl estradiol/ferrous fumarate/norethindrone
• estradiol/norethindrone
• Femlyv (ethinyl estradiol, norethindrone)
• ethinyl estradiol/norethindrone (Junel Fe)
• mestranol/norethindrone
• Ortho-Norvum 1/50, Genora 1/50, Nelova 1/50M, Norinyl 1+50
• Ovcon-50
• Ortho-Norvum 1/35, Genora 1/35, NEE 1/35, Nelova 1/35E, Norethin 1/35E, Norinyl 1+35
• Brevicon, Modicon, Genora 0.5/35, Nelova 0.5/35
• Ovcon-35
• Activella
• Femhrt (ethinyl estradiol, norethindrone)
• Loestrin 21 1.5/30, Loestrin Fe 1.5/30
• Loestrin 21 1/20, Loestrin Fe 1/20
• Ortho-Novum 10/11, Jenest-28, Nelova 10/11
• Ortho-Novum 7/7/7, Tri-Norinyl, Estrostep
• Combipatch
• Loestrin 24 Fe

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6230
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4536
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5289004