loxapine (Loxitane, Dibenzoazepine, Cloxazepin)

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Introduction

Tradename: Loxitane.

Indications

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

  • 12.5-50 mg IM every 4-6 hours, PRN.
  • start 10 mg PO BID
  • usual effective dose: 60-100 mg//day divided BID-QID
  • max 250 mg/day

Tabs: 5, 10, 25, 50 mg.

Liquid: 25 mg/mL.

Pharmacokinetics

elimination via liver

elimination via kidney

Adverse effects

* Most frequent in women in 4th-10th week of therapy

# Usually after large doses for prolonged periods

Drug interactions

(see chlorpromazine)

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Schneeweiss S et al, Risk of death with use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ 2007, 176:627 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17325327

Database