histamine H1 receptor (HRH1)

Function

• action may be mediated via phosphoinositide hydrolysis
• in peripheral tissues, histamine H1 receptors:
  • mediate contraction of smooth muscles
  • increase capillary permeability due to contraction of terminal venules
  • mediate catecholamine release from adrenal medulla
• in CNS, histamine H1 receptors mediate neurotransmission
• potential sites of phosphorylation in the 3rd cytoplasmic loop may play a role in regulating signal transduction
• blockade causes weight gain & sedation

Structure

• belongs to the G-protein coupled receptor 1 family
• membrane pocket formed by 7 transmembrane regions forms ligand binding site & provides for interaction of receptor with G protein

Compartment

cell membrane

More general terms

• histamine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3269
• OMIM: https://mirror.omim.org/entry/600167
• UniProt: http://www.uniprot.org/uniprot/P35367.html