dopamine D3 receptor (DRD3)

Function

• one of the five types dopamine receptor
• activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
• interacts with CLIC6 (putative)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

brain

Pathology

• genetic variation in DRD3 may be associated with susceptibility to hereditary essential tremor 1

More general terms

• dopamine receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1814
• OMIM: https://mirror.omim.org/entry/126451
• OMIM: https://mirror.omim.org/entry/190300
• UniProt: http://www.uniprot.org/uniprot/P35462.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1814