cerebrovascular disease/disorder
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Etiology
- atherosclerosis
- advanced age
- hypertension
- excessive dietary salt may contribute to progression of cerebral small vessel disease in older adults[9]
- effects of salt may be mediated in part by hypertension
- excessive dietary salt may contribute to progression of cerebral small vessel disease in older adults[9]
- arterial embolism
- cerebral vasculitis
- cerebral amyloid angiopathy
Epidemiology
- as common as cardiovascular disease[1]
Pathology
Clinical manifestations
- may have difficulty rising from chair
- difficulty starting to walk
- slow gait
- diminished foot clearance
- tendency to fall backward[2]
Diagnostic procedures
- poor performance on the trailmaking B test may be a manifestation of unrecognized cerebrovascular disease[3][4]
Radiology
- MRI neuroimaging to score cerebral small-vessel disease may help predict dementia[7]
Complications
Management
- medical therapy better than intracranial stenting
- benefit of intracranial angioplasty without stenting has not been demonstrated[6]
- treat hypertension
- reducing dietary salt my reduce risk[9]
- treat dyslipidemia
More general terms
More specific terms
- basilar artery disease
- carotid artery disease
- cerebral amyloid angiopathy (CAA)
- cerebrovascular hemorrhage
- intracranial arterial stenosis
- Moyamoya disease
- stroke; cerebrovascular accident (CVA)
- vascular dementia
References
- ↑ 1.0 1.1 Rothwell PM et al, Population-based study of event-rate, incidence, case-fatality, and mortality for all acute vascular events in all arterial territories. (Oxford Vascular Study) Lancet 2005; 366:1773 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16298214
- ↑ 2.0 2.1 Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
- ↑ 3.0 3.1 Wiberg R et al Cognitive function and risk of stroke in elderly men Neurology, 2010 74(5):379-385 http://www.neurology.org/content/74/5/379
- ↑ 4.0 4.1 Wiberg B et al The relationship between executive dysfunction and post-stroke mortality: A population-based cohort study. BMJ Open 2012 May 9; 2:e000458 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22573701
- ↑ Turan TN, Cotsonis G, Lynn MJ et al Relationship between blood pressure and stroke recurrence in patients with intracranial arterial stenosis. Circulation. 2007 Jun 12;115(23):2969-75. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17515467
- ↑ 6.0 6.1 Derdeyn CP et al. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): The final results of a randomised trial. Lancet 2013 Oct 26 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24168957 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62038-3/fulltext
- ↑ 7.0 7.1 7.2 Amin Al Olama A et al. Simple MRI score aids prediction of dementia in cerebral small vessel disease. Neurology 2020 Mar 24; 94:e1294. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32123050 https://n.neurology.org/content/94/12/e1294
- ↑ 8.0 8.1 Jacob MA et al. Cerebral small vessel disease progression increases risk of incident parkinsonism. Ann Neurol 2023 Feb 10; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36762437 https://onlinelibrary.wiley.com/doi/10.1002/ana.26615
- ↑ 9.0 9.1 9.2 Liu D, Zhang Q, Xing S et al Excessive salt intake accelerates the progression of cerebral small vessel disease in older adults. BMC Geriatrics. 2023. May 2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37131130 PMCID: PMC10155382 Free PMC article https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-023-03877-3