leukoaraiosis

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Introduction

Diffuse subcortical white matter disease seen on magnetic resonance neuroimaging. see MRI cerebral white matter lesion

Etiology

Epidemiology

Clinical manifestations

Radiology

Comparative biology

Additional terms

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 2352
  2. Inzitari D et al Changes in white matter as determinant of global functional decline in older independent outpatients: Three year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ 2009 Jul 6; 339:b2477 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19581317 <Internet> http://dx.doi.org/10.1136/bmj.b2477
  3. 3.0 3.1 NEJM Question of the Week. Dec 6, 2016 http://knowledgeplus.nejm.org/question-of-week/1365/
  4. Vermeer SE et al. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003 Mar 28; 348:1215. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/12660385 Free full text <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa022066
  5. 5.0 5.1 Montagne A, Nikolakopoulou AM, Zhao Z et al Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nature Medicine Feb 5, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29400711 https://www.nature.com/articles/nm.4482
  6. 6.0 6.1 Huynh K et al. Clinical and biological correlates of white matter hyperintensities in patients with behavioral-variant frontotemporal dementia and Alzheimer disease. Neurology 2021 Feb 17; [e-pub] https://n.neurology.org/content/96/13/e1743