alpha-2 adrenergic receptor
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Function
- alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins
- rank order of potency for agonists: oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine
- rank order of potency for antagonists: yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
- presynaptic autoreceptor
- norepinephrine inhibits further release of norepinephrine
- presynaptic heteroreceptor on serotoninergic neurons
- norepinephrine interaction stimulates further release of serotonin
More general terms
More specific terms
- alpha-2A adrenergic receptor; alpha-2A adrenoreceptor; alpha-2A adrenoceptor; alpha-2AAR; alpha-2 adrenergic receptor subtype C10 (ADRA2A, ADRA2R, ADRAR)
- alpha-2B adrenergic receptor; alpha-2B adrenoreceptor; alpha-2B adrenoceptor; alpha-2 adrenergic receptor subtype C2 (ADRA2B ADRA2L1 ADRA2RL1)
- alpha-2C adrenergic receptor; alpha-2C adrenoreceptor; alpha-2C adrenoceptor; alpha-2 adrenergic receptor subtype C4 (ADRA2C, ADRA2L2, ADRA2RL2)
- alpha-2D adrenergic receptor
Additional terms
References
- ↑ VanDongen AM, Codina J, Olate J, Mattera R, Joho R, Birnbaumer L, Brown AM. Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science. 1988 Dec 9;242(4884):1433-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3144040
- ↑ Sagi-Eisenberg R GTP-binding proteins as possible targets for protein kinase C action TIBS 14:355 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2512697
- ↑ Ross CA, McInnis MG, Margolis RL, Li SH. Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends Neurosci. 1993 Jul;16(7):254-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7689767