dapsone (Avlosulfon)

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Introduction

Tradename: Avlosulfon.

Indications

Contraindications

Caution:

pregnancy category = c

safety in lactation = -

Dosage

Tabs: 25 & 100 mg. Aczone: topical gel for acne

Dosage adjustment in renal failure

  • dose adjustment may be necessary with renal impairment.
  • no specific guidelines available

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 20-30 hours

Monitor

Adverse effects

Drug interactions

Mechanism of action

More general terms

More specific terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Medical Knowledge Self Assessment Program (MKSAP) 11, 18. American College of Physicians, Philadelphia 1998, 2018
  5. Prescriber's Letter 13(2): 2006 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220215&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. 6.0 6.1 Prescriber's Letter 16(1): 2009 COMMENTARY: New Drug: Aczone (Dapsone) Gel 5% GUIDELINES: Acne Vulgaris Management GUIDELINES: Recommendations for Acne Management Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250112&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 7.2 7.3 7.4 Deprecated Reference
  8. 8.0 8.1 8.2 Tangamornsuksan W, Lohitnavy M. Association Between HLA-B*1301 and Dapsone-Induced Cutaneous Adverse Drug Reactions. A Systematic Review and Meta-analysis. JAMA Dermatol. 2018 Mar 14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29541744
  9. 9.0 9.1 Liang SE, Hoffmann R, Peterson E et al. Use of dapsone in the treatment of chronic idiopathic and autoimmune urticaria. JAMA Dermatol 2018 Nov 21; 155:90. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30476976 https://jamanetwork.com/journals/jamadermatology/fullarticle/2715087

Database