ethionamide (Trecator-SC)
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Introduction
Tradename: Trecator-SC
Indications
- treatment of tuberculosis & other mycobacterial infections, including Mycobacterium avium complex
- used in conjunction with other anti-tuberculous agents when 1st line therapy has failed or resistance has been demonstrated
Contraindications
severe hepatic impairment
Caution: use with caution in patients taking isoniazid or cycloserine
Dosage
- 500-1000 mg/day divided BID
- children 15-20 mg/kg/day divided BID; max 1000 mg/day
- take with meals
- neurotoxic effects may be relieved by coadministration of pyridoxine 50 mg QD
Tabs: 250 mg. Dose adjustment in renal failure:
| creatinine clearance | dosage |
|---|---|
| 10-50 mL/min | 100% |
| < 10 mL/min | 50% of dose |
Pharmacokinetics
- elimination 1/2life 2.1 hours
elimination via liver
Adverse effects
- common (> 10%)
- less common (1-10%)
- hepatitis, jaundice, peripheral neuritis, psychiatric disorder, postural hypotension, metallic taste
- uncommon (< 1%)
- other
Drug interactions
- cycloserine
- isoniazid
- increased toxicity with rifampin
- drug interaction(s) anticonvulsants with anti-bacterial agents
- drug interaction(s) of antibiotics with warfarin
Test interactions
- decreased serum thyroxine
More general terms
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ Deprecated Reference
- ↑ 4.0 4.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
- ↑ Department of Veterans Affairs, VA National Formulary