sulfamethoxazole [SMX] (Gantanol, Aposulfatrim, Bactoreduct)
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Introduction
Tradename: Gantanol. Alias SMX.
Dosage
Tabs: 500 mg.
Syrup: 500 mg/5 mL.
Dosage adjustment in renal failure
Table
| creatinine clearance | dosage |
|---|---|
| > 50-90 mL/min | 12 hour dosing |
| 10-50 mL/min* | 18 hour dosing |
| < 10 mL/min# | 24 hour dosing |
* same dose for continuous arteriovenous hemofiltration
# 1 g after hemodialysis
Pharmacokinetics
elimination via kidney
Adverse effects
- crystals, insoluble in urine[3]
- may lead to acute renal failure, reversible with discontinuation of drug
- 2-fold increased risk of miscarriage
- thromobocytopenia[5]
- drug adverse effects of sulfonamides
- drug adverse effects of diuretics
- drug adverse effects of carbonic anhydrase inhibitor(s)
- drug adverse effects of antihypertensive agents
Laboratory
Therapeutic range:
More general terms
Component of
- phenazopyridine/sulfamethoxazole/trimethoprim
- trimethoprim/sulfamethoxazole; cotrimoxazole (Bactrim, Septra, Cotrim, Sulfatrim, Sulfoxatrim, Trisulfam, Uroplus)
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Sanford Guide to antimicrobial therapy 2001
- ↑ 3.0 3.1 Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004
- ↑ Muanda FT, Sheehy O, Berard A Use of antibiotics during pregnancy and risk of spontaneous abortion. CMAJ 2017 May 1;189:E625-33 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28461374 <Internet> http://www.cmaj.ca/content/189/17/E625.full.pdf+html
- ↑ 5.0 5.1 Curtis BR, McFarland JG, Wu GG Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. Blood. 1994 Jul 1;84(1):176-83. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7517207 Free article.