amoxicillin/clavulanate (Augmentin)

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Introduction

Tradename: Augmentin.

Indications

Contraindications

Dosage

Tabs: 125, 250, 500 mg.

Elixir: 125 250 mg/5 mL.

Suspension:

ES-600: 600 mg amoxicillin/5mL[5]

Augmentin XR: 1000 mg amoxicillin & 62.5 mg clavulanate[7] 1-2 tablets PO BID

Generic:

Storage

Pharmacokinetics

Antimicrobial activity

Gram positive

Gram negative

Anaerobes

Adverse effects

(uncommon < 1%)

* most common pharmaceutical agent causing hepatotoxicity[8]

* treatment of hepatotoxicity is supportive

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Components

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Sanford Guide to antimicrobial therapy 1997
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. 5.0 5.1 5.2 5.3 Prescriber's Letter 8(11):63 2001
  6. 6.0 6.1 Prescriber's Letter 9(9):51 2002
  7. 7.0 7.1 Prescriber's Letter 9(10):58 2002
  8. 8.0 8.1 Chalasani N et al. for the Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 2008 Dec; 135:1924. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18955056
  9. 9.0 9.1 Yudin MH et al Antibiotic therapy in preterm premature rupture of the membranes. J Obstet Gynaecol Can. 2009 Sep;31(9):863-7, 868-74. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19941711
  10. 10.0 10.1 10.2 10.3 10.4 Deprecated Reference
  11. 11.0 11.1 Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300622&pb=PRL (subscription needed) http://www.prescribersletter.com
  12. Lucena MI, Andrade RJ, Fernandez MC et al Determinants of the clinical expression of amoxicillin- clavulanate hepatotoxicity: a prospective series from Spain. Hepatology. 2006 Oct;44(4):850-6 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17006920
  13. NEJM Knowledge+ Gastroenterology

Database