clavulanate (clavulanic acid)
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Introduction
Clavulanic acid is produced by Streptomyces clavuligerus. It has poor intrinsic antimicrobial activity, but is a suicide inhibitor of beta-lactamases produced by a wide range of Gram+ & Gram- microorganisms. It is well absorbed by mouth, but can be given parenterally. It has been combined with amoxicillin as an oral preparation (Augmentin) & with ticarcillin in a parenteral preparation (Timentin).
More general terms
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References
- ↑ The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 1093