ticarcillin clavulanate (Timentin)

Introduction

Tradename: Timentin.

Indications

• bacterial infections due to susceptible organisms
• skin or soft tissue infection
  • diabetic foot infection
• intra-abdominal infection
  • diverticulitis
• infectious arthritis, osteomyeltitis
• empiric treatment of febrile neutropenia
• empiric treatment for fever of unknown origin
• pneumonia

Contraindications

pregnancy-category B

safety in lactation ?

Dosage

3.1 g IV every 4-6 hours

Dosage adjustment in renal failure

Table

creatinine clearance	dosage
> 50-90 mL/min	3.1 g every 4 hours
10-50 mL/min	2.0 g every 4-8 hours
< 10 mL/min*	2.0 g every 12 hours

* extra 3.1 g after hemodialysis

Pharmacokinetics

elimination: kidney

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
  • Streptococcus pneumonia
  • Streptococcus viridans, milleri
• Enterococcus faecalis (+/-)
• Enterococcus faecium (+/-)
• Staphylococcus aureus (MSSA)
• Staphylococcus epidermidis (+/-)
• Listeria monocytogenes

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Moraxella catarrhalis
• Haemophilus influenzae
• Escherichia coli
• Klebsiella species
• Enterobacter species
• Serratia species
• Salmonella species
• Proteus mirabilis
• Proteus vulgaris
• Providencia species
• Morganella species
• Citrobacter species
• Aeromonas species
• Acinetobacter species
• Pseudomonas aeruginosa
• Xanthomonas maltophilia
• Yersinia enterocolitica
• Pasteurella multocida

Anaerobes

• Bacteroides fragilis
• Bacteroides melaninogenicus
• Clostridium species
• Peptostreptococcus species

Laboratory

• ticarcillin clavulanate in serum/plasma

More general terms

• beta-lactam/beta-lactamase inhibitor

Components

• ticarcillin (Ticar)
• clavulanate (clavulanic acid)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=104960