tyrosine-protein kinase ABL2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; tyrosine-protein kinase ARG (ABL2, ABLL, ARG)

Function

• regulates cytoskeleton remodeling during cell differentiation, cell division & cell adhesion
• localizes to dynamic actin structures, & phosphorylates CRK & CRKL, DOK1, & other proteins controlling cytoskeleton dynamics
• phosphorylates PSMA7 that leads to an inhibition of proteasomal activity & cell cycle transition blocks
• Stabilized in the inactive form by an association between the SH3 domain & the SH2-TK linker region, interactions of the amino-terminal cap, & contributions from an amino-terminal myristoyl group & phospholipids
• activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation
• activated by RIN1 binding to the SH2 domain & SH3 domain
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with PSMA7

Cofactor: Mg+2 or Mn+2

ATP + protein-L-tyrosine = ADP + protein-L-tyrosine phosphate

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, ABL subfamily
• contains 1 protein kinase domain
• contains 1 SH2 domain
• contains 1 SH3 domain

Compartment

cytoplasm, cytoskeleton

Alternative splicing

named isoforms=4; IB, IA, IC

Expression

widely expressed

Pharmacology

• inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML)

More general terms

• abl protein
• proto oncogene protein
• myristoylated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27; -.
• OMIM: https://mirror.omim.org/entry/164690
• UniProt: http://www.uniprot.org/uniprot/P42684.html