14-3-3 protein sigma; stratifin; epithelial cell marker protein 1 (SFN HME1)

Function

• adapter protein implicated in regulation of both general & specialized signaling pathways
• binds to many protein, usually by recognition of a phospho-Ser or phospho-Thr motif
• binding generally results in modulation of the activity of the binding partner
• when bound to KRT17, regulates protein synthesis & epithelial cell growth by stimulating Akt/mTOR pathway (putative)
• p53-regulated inhibitor of G2/M progression
• overexpression in human cells leads to increase in cell size & arrest in G2 phase
• interacts with KRT17 (putative)
• found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 & SFN

Structure

• homodimer.
• belongs to the 14-3-3 family

Compartment

• cytoplasm, nucleus
• may be secreted by a non-classical secretory pathway

Alternative splicing

named isoforms=2

Expression

• present mainly in tissues enriched in stratified squamous epithelium (keratinizing)

More general terms

• 14-3-3 protein (KCIP-1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2810
• OMIM: https://mirror.omim.org/entry/601290
• UniProt: http://www.uniprot.org/uniprot/P31947.html