vacuolar protein sorting-associated protein 35 (vesicle protein sorting 35, hVPS35, maternal-embryonic 3, VPS35, MEM3, TCCCTA00141)

From Aaushi
Jump to navigation Jump to search

Function

Compartment

cytoplasm, membrane, peripheral membrane

Alternative splicing

named isoforms=2

Expression

Pathology

  • reduced expression occurs spatially and temporally in parallel with progression of Alzheimer's disease[2]
  • VPS35 regulates Abeta peptide levels

More general terms

Component of

References

  1. UniProt http://www.uniprot.org/uniprot/Q9UBQ0.html
  2. 2.0 2.1 2.2 Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, Honig L, Vonsattel JP, Kim TW. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol. 2005 Dec;58(6):909-19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16315276

Database