vacuolar protein sorting-associated protein 35 (vesicle protein sorting 35, hVPS35, maternal-embryonic 3, VPS35, MEM3, TCCCTA00141)
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Function
- component of the retromer complex
- interacts directly with VPS26A & VPS26B
- found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 & SFN
Compartment
cytoplasm, membrane, peripheral membrane
Alternative splicing
named isoforms=2
Expression
- ubiquitous
- expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney, colon
- expression of protein inversely related to mRNA levels[2]
Pathology
- reduced expression occurs spatially and temporally in parallel with progression of Alzheimer's disease[2]
- VPS35 regulates Abeta peptide levels
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UBQ0.html
- ↑ 2.0 2.1 2.2 Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, Honig L, Vonsattel JP, Kim TW. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol. 2005 Dec;58(6):909-19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16315276