Rho-GTPase-activating protein 1 (Rho-related small GTPase protein activator, CDC42 GTPase-activating protein, P50-rhoGAP, ARHGAP1)

Function

• GTPase activator for the Rho, Rac & Cdc42 proteins, converting them to the putatively inactive GDP-bound state
• Cdc42 seems to be the preferred substrate
• found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 & SFN
• interacts with BNIPL

Structure

• contains 1 CRAL-TRIO domain
• contains 1 Rho-GAP domain

Compartment

cytoplasm

Expression

ubiquitous

Notes

• unclear how this protein is related to CDGAP

More general terms

• rho GTPase-activating protein (rho-GAP)

Additional terms

• Cdc42 GTPase-activating protein (CDGAP, ARHGAP31, KIAA1204)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:392
• OMIM: https://mirror.omim.org/entry/602732
• UniProt: http://www.uniprot.org/uniprot/Q07960.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=392