vacuolar protein sorting-associated protein 26A (vesicle protein sorting 26A, hVPS26A, VPS26A, VPS26)

Function

• component of the retromer complex
• interacts directly with VPS35
• found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35, SFN

Compartment

• cytoplasm, endosome, endosomal membrane, peripheral membrane

Pathology

• down-regulated in Alzheimer disease, may be associated with down-regulation of the retromer complex
• no polymorphism or variant associated with AD

More general terms

• vacuolar protein sorting-associated protein (VPS)
• protein subunit

Component of

• retromer complex

Database

• OMIM: https://mirror.omim.org/entry/605506
• UniProt: http://www.uniprot.org/uniprot/O75436.html