retromer complex
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Function
- regulates trafficking of type-1 membrane proteins from endosome to trans-Golgi
- retrieves lysosomal enzyme receptors (IGF2R & M6PR) from endosomes to the trans-Golgi network
- regulates transcytosis of the polymeric immunoglobulin receptor
- regulates trafficking of VPS10 domain-containing proteins
- APP, BACE, presenilin-1, & apoE among retromer complex cargo[3]
- SorLA may be receptor for retromer complex[3]
Structure
Pathology
- reduced expression of retromer or its subunit VPS35 results in redistribution or mistrafficking of its cargo[2]
- subunit VPS35 regulates Abeta peptide levels
- expression diminished in spatiotemporal parallel with Alzheimer's disease (diminished expression conforms to spatiotemporal model of AD based upon Braak staging)
Notes
- ref[4] discusses age-related pathways that interact with retromer function
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UBQ0.html
- ↑ 2.0 2.1 Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, Honig L, Vonsattel JP, Kim TW. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol. 2005 Dec;58(6):909-19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16315276
- ↑ 3.0 3.1 3.2 Verges M., Luton F., Gruber C., Tiemann F., Reinders L.G., Huang L., Burlingame A.L., Haft C.R., Mostov K.E.; The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor Nat Cell Biol 2004, 6:763-769 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15247922
- ↑ 4.0 4.1 Wilson KA The understudied links of the retromer complex to age-related pathways. GeroScience. 2022. 44, 19-24 https://link.springer.com/article/10.1007/s11357-021-00430-1