polymeric immunoglobulin receptor; poly-Ig receptor; PIGR; hepatocellular carcinoma-associated protein TB6 (PIGR)

Function

• binds polymeric IgA & IgM at the basolateral surface of epithelial cells
• the receptor complex is then transported across the cell to be secreted at the apical surface
• during this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment

Structure

• N-glycosylation is not necessary for Ig binding
• contains 5 Ig-like V-type domains (immunoglobulin-like)

Compartment

• cell membrane
• secretory component: secreted

More general terms

• cell surface receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5284
• OMIM: https://mirror.omim.org/entry/173880
• UniProt: http://www.uniprot.org/uniprot/P01833.html