insulin-like growth factor [IGF]-2 receptor (CD222, somatomedin MSA receptor, cation-independent mannose-6-phosphate receptor, MPR 300, CI-MPR, M6PR, MPRI, IGF2R)

^[1]^[2]^[3]^[4]^[5]

Function

binds IGF2
- as receptor for IGF2, may play a role in consolidation & reconsolidation of memories
transport of phosphorylated lysosomal enzymes from the Golgi & the cell surface to lysosomes
lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi & the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex
positive regulator of T-cell coactivation by binding DPP4
also binds GGA1, GGA2 & GGA3

contains 15 repeating units of approximately 147 AA
the most highly conserved region within the repeat consists of a stretch of 13 AA that contains Cys at both ends
belongs to the MRL1/IGF2R family
contains 1 fibronectin type-2 domain

lysosome membrane
colocalizes with DPP4 in internalized cytoplasmic vesicles adjacent to cell surface

↑ Nishibe S et al Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains. Proc Natl Acad Sci U S A. 1990 Jan;87(1):424-8. Erratum in: Proc Natl Acad Sci U S A 1990 Apr;87(8):3253. Kim JJ [corrected to Kim JW]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2153302
↑ Cross M, Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell. 1991 Jan 25;64(2):271-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988148
↑ Nishimoto I, Murayama Y, Katada T, Ui M, Ogata E. Possible direct linkage of insulin-like growth factor-II receptor with guanine nucleotide-binding proteins. J Biol Chem. 1989 Aug 25;264(24):14029-38. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2547780
↑ UniProt http://www.uniprot.org/uniprot/P11717.html
↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/IGF2RID380.html