sorting nexin-2; transformation-related gene 9 protein; TRG-9 (SNX2)

Function

• may be involved in several stages of intracellular trafficking
• component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R & M6PR) from endosomes to the trans-Golgi network
• interacts with FNBP1

Structure

• belongs to the sorting nexin family
• contains 1 PX (phox homology) domain

More general terms

• sorting nexin
• phosphoprotein

Component of

• retromer complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6643
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6643
• OMIM: https://mirror.omim.org/entry/605929
• UniProt: http://www.uniprot.org/uniprot/O60749.html