low-density lipoprotein receptor relative with 11 ligand-binding repeats; sortilin-related receptor; sorting protein-related receptor containing LDLR class A repeats; LDLR relative with 11 ligand-binding repeats (SorLA, SorLA-1, LR11, SORL1)

Function

• multifunctional endocytic receptor
• implicated in the uptake of lipoproteins & proteases
• binds LDL & transports it into cells by endocytosis
• binds the receptor-associated protein (p39RAP)
• cell-cell interaction
• propeptide removed in the N-terminus may be cleaved by furin
• may be receptor for retromer complex

Structure

• belongs to the SORL1 family
• contains 5 BNR repeats
• contains 1 EGF-like domain
• contains 6 fibronectin F3 modules
• contains 11 LDL-receptor class A domains
• contains 5 LDL-receptor class B repeats

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Expression

• expressed mainly in brain
• abundant in the cerebral cortex, entorhinal cortex, occipital pole, cerebellum
• low expression in the putamen, thalamus
• may be expressed at lower levels in spinal cord, testis, pancreas, placenta, heart, prostate, ovary, thyroid, spleen

Pathology

• has been implicated in AD
• has putative APP-binding domain

More general terms

• VPS10 domain-containing protein (VPS10)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6653
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6653
• OMIM: https://mirror.omim.org/entry/602005
• UniProt: http://www.uniprot.org/uniprot/Q92673.html