Cdc42 GTPase-activating protein (CDGAP, ARHGAP31, KIAA1204)

Function

• GTPase-activating protein (GAP) for RAC1 & CDC42
• required for cell spreading, polarized lamellipodia formation & cell migration
• interacts with ITSN1, which inhibits GAP activity
• interacts with PARVA (putative)
• phosphorylation on Thr-789 reduces GAP activity

Structure

contains 1 Rho-GAP domain

Compartment

• cell projection, lamellipodium, cell junction, focal adhesion (putative)

Expression

mainly expressed in fetal heart & muscle Unclear how this protein is related to ARHGAP1

More general terms

• rho GTPase-activating protein (rho-GAP)

Additional terms

• Rho-GTPase-activating protein 1 (Rho-related small GTPase protein activator, CDC42 GTPase-activating protein, P50-rhoGAP, ARHGAP1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5751
• UniProt: http://www.uniprot.org/uniprot/Q2M1Z3.html