very low-density lipoprotein receptor; VLDL receptor; VLDL-R (VLDLR)

Function

• binds VLDL & transports it into cells by endocytosis
• receptor-ligand complexes cluster into clathrin-coated pits prior to endocytosis
• binding to Reelin induces Tyr phosphorylation of Dab1 & modulation of Tau phosphorylation (putative)
• binds to the extracellular matrix protein Reelin
• interacts with VLDLR
• interacts with SNX17 (putative)
• interacts with DAB1
• receptor for the minor-group human rhinoviruses (HRVs)
• binds protein VP1 through the 2nd & 3rd LDL-receptor class A domains
• VLDL receptor binds apolipoprotein E

Structure

• contains 3 EGF-like domains
• contains 8 LDL-receptor class A domains
• contains 6 LDL-receptor class B repeats

Compartment

• membrane
• clathrin-coated pit

Alternative splicing

named isoforms=2

Expression

• abundant in heart & skeletal muscle
• also expressed in ovary & kidney
• tissue distribution of the VLDL receptor is very different from the LDL receptor
• mRNA for the VLDL receptor is abundant in cells with active fatty acid metabolism, including heart, muscle & adipose tissue
• very little is expressed in liver.

Pathology

• deletions involving VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia

More general terms

• lipoprotein receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7436
• OMIM: https://mirror.omim.org/entry/192977
• OMIM: https://mirror.omim.org/entry/224050
• UniProt: http://www.uniprot.org/uniprot/P98155.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7436