APP secretase
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Introduction
One of the proteases that cleaves the amyloid precursor protein with with a the N-terminal fragment into the exoplasmic space. Concerted activity of the beta & gamma secretase also result in formation of the A4 amyloid peptide (A-beta). Cleavage by alpha- secretase precludes formation of A-beta.
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References
- ↑ Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343