pen-2 protein; presenilin enhancer protein 2; gamma-secretase subunit pen-2 (PSENEN)

Function

• part of APP gamma-secretase complex
• Pen-2 is required for endoproteolytic processing of presenilin & conferring gamma-secretase activity

Structure

belongs to the PEN-2 family

Compartment

• endoplasmic reticulum membrane
• Golgi stack membrane
• predominantly located in the endoplasmic reticulum & in the cis-Golgi

Expression

• widely expressed
• expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart & brain

Pathology

• one of 3 components of APP gamma-secretase complex in which haploinsufficiency is associated with hidradenitis suppurativa

More general terms

• protein subunit
• transmembrane 2e protein

Component of

• APP gamma-secretase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5585
• OMIM: https://mirror.omim.org/entry/607632
• UniProt: http://www.uniprot.org/uniprot/Q9NZ42.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55851