solute carrier family 5 member 7 (SLC5A7, high-affinity choline transporter 1, hemicholinium-3-sensitive choline transporter, CHT, CHT1)

Function

• imports choline from extracellular space into neurons with high affinity
• Na+ & Cl- dependent
• phosphorylated (putative)
• inhibited by nanomolar concentrations of hemicholinium 3

Structure

• belongs to the Na+:solute symporter (SSF) (TC 2.A.21) family

Compartment

membrane

Expression

• expressed in putamen, spinal cord & medulla oblongata
• specific for cholinergic neurons

More general terms

• transmembrane 12 protein
• solute carrier family 5 (SLC5, SLC5A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6048
• OMIM: https://mirror.omim.org/entry/608761
• UniProt: http://www.uniprot.org/uniprot/Q9GZV3.html