APP C99 peptide fragment
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Introduction
C-terminal peptide fragment generated from the amyloid precursor protein (APP) by APP beta-secretase. It serves as a substrate for gamma-secretase with formation the A4 amyloid peptide (A-beta).
More general terms
Additional terms
- amyloid precursor protein; A4/beta amyloid precursor protein (APP)
- APP beta-secretase or beta-site APP-cleaving enzyme (BACE)
- APP gamma-secretase
References
- ↑ Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343