neuropil threads
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Structure
- contain paired helical filaments with hyperphosphorylated (PHF) tau
Pathology
- occur in axons & dendrites
- seen in
- Alzheimer's disease - most prominant in select subfields & layers of ventromedial temporal lobe & association cortex
- corticobasal degeneration
- progressive supranuclear palsy
- frontotemporal dementia with parkinsonism
More general terms
References
- ↑ Mitchell TW, Nissanov J, Han LY et al. J Histochem Cytochem. 2000 Dec;48(12):1627-38. Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11101631