microtubule-associated protein tau in serum/plasma
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Pathology
- marker of axonal damage[1]
- higher plasma total tau level associated with:[3]
- poorer cognition across 7 cognitive tasks
- smaller hippocampal volume
- neurofibrillary tangles*
- microinfarcts*
* at autopsy
Indications
- evaulation of cerebral concussion[1]
- specifying target populations for trials that focus on behavior[5]
Reference interval
- reported in picograms per milliliter
Clinical significance
- one hour post head injury plasma levels predict time to symptom resolution
- repeated head trauma predicts later life plasma total tau in NFL players[2]
- plasma total tau at least as strongly associated with incident Alzheimer's dementia as CSF tau[3]
- baseline plasma total tau in connection with plasma neurofilament light chain associated with worse global cognition & memory loss & with neuroimaging, including temporal cortex thickness & increased number of infarcts, but did not add to prognostic value over 6 year period[4]
- 5x higher concentrations of serum total tau associated with increased risk of overall mortality (RR=1.46)[6]
Notes
- physical activity associated with slower cognitive decline, more so in persons with higher plasma total tau[5]
More general terms
More specific terms
Additional terms
Component of
- PrecivityAD2 blood test algorithm; amyloid probability score 2 (APS2); plasma ptau217/total tau + amyloid-beta-42/amyloid-beta-40 in plasma
- phosphorylated tau/total tau in serum/plasma
References
- ↑ 1.0 1.1 1.2 Shahim P et al Blood Biomarkers for Brain Injury in Concussed Professional Ice Hockey Players. JAMA Neurol. Published online March 13, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24627036 <Internet> http://archneur.jamanetwork.com/article.aspx?articleid=1846623
Gatson J and Diaz-Arrastia R Tau as a Biomarker of Concussion JAMA Neurol. Published online March 13, 2014. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24627000 <Internet> http://archneur.jamanetwork.com/article.aspx?articleid=1846622 - ↑ 2.0 2.1 Bassett M Plasma Total-Tau Level May Flag CTE - Lack of biomarker frustrates CTE researchers. MedPage Today. April 24, 2017 https://www.medpagetoday.com/MeetingCoverage/AAN/64766
Alosco M, et al An investigation on repetitive head impact exposure and plasma total tau concentrations in former National Football League players American Academy of Neurology 2017 Annual Meeting - ↑ 3.0 3.1 3.2 Pase MP, Beiser AS, Himali JJ et al Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes. JAMA Neurol. Published online March 4, 2019. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30830207 https://jamanetwork.com/journals/jamaneurology/fullarticle/2726948
- ↑ 4.0 4.1 George J Blood-Based Markers Tied to Brain Cell and Memory Loss. Another step closer to clinical utility for tracking neurodegeneration. MedPage Today April 16, 2021 https://www.medpagetoday.com/meetingcoverage/aan/92140
Marks J, et al Comparison of neurofilament light and total tau as blood-based biomarkers of neurodegeneration: associations with cognition and neuroimaging outcomes. American Academy of Neurology (AAN) 2021. - ↑ 5.0 5.1 5.2 Desai P, Evans D, Dhana K et al Longitudinal Association of Total Tau Concentrations and Physical Activity With Cognitive Decline in a Population Sample. JAMA Netw Open. 2021;4(8):e2120398. Aug 11 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34379124 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2782979
- ↑ 6.0 6.1 Halloway S et al Serum total tau, neurofilament light, and glial fibrillary acidic protein are associated with mortality in a population study. J Am Geriatr Soc. 2024 Jan;72(1):149-159 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37818793 https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.18632