brain-derived microtubule-associated protein tau in serum/plasma

Indications

• may be useful for evaluation of tauopathy
  • may be useful for detecting Alzheimer's-related neurodegeneration & differentiating Alzheimer's disease from other neurodegenerative diseases

Clinical significance

• correlates with microtubule-associated protein tau in CSF

Procedure

• brain-derived microtubule-associated protein tau differs from peripherally-derived tau that contains an exon 4a insert between exons 4 & 5*
• an antibody that binds to an expressed glutathione-S-transferase-protein-linked protein construct for the MAPT gene exons 4-5 & of tau recombinant full length tau-441 was developed
• the resulting TauJ.5H3 monoclonal antibody demonstrates specific reactivity to the junction between MAPT exons 4 & 5, excluding tau of peripheral origin with an exon 4a insert
• levels of brain-derived microtubule-associated protein tau in serum/plasma using the TauJ.5H3 monoclonal correlate microtubule-associated protein tau in CSF

More general terms

• microtubule-associated protein tau in serum/plasma

Additional terms

• microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1)