MAPT (microtubule-associated protein tau) gene

Introduction

16 exons (exons 0-14 & exon 4a).

Alternative splicing

• microtubule associated protein tau forms generated by alternative splicing of 11 of 16 exons
• exon 0 is part of the promoter
• exons 9, 10, 11, & 12 encode microtubule-binding domains
• exons 1, 4, 5, 7, 9, 11, 12, & 13 are constitutively expressed
• splicing of exons 2, 3 & 10 produce 6 alternatively spliced forms
• thus 3 or 4 microtubule-binding domains occcur in tau forms depending upon alternative splicing of exon 10
• exons 6 & 8 are not transcribed in human CNS

More general terms

• unclassified gene

Database

• OMIM: https://mirror.omim.org/entry/157140