PrecivityAD2 blood test algorithm; amyloid probability score 2 (APS2); plasma ptau217/total tau + amyloid-beta-42/amyloid-beta-40 in plasma
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Indications
- diagnostic workup for potential Alzheimer's disease
Methods
Procedure
- plasma ptau217/total tau + plasma amyloid-beta-42/40
- no difference in diagnostic accuracy between APS2 & plasma ptau217 alone[1]
Notes
- clinically usedful[2]
More general terms
Components
- phosphorylated tau(Thr)217 in serum/plasma (plasma ptau217)
- microtubule-associated protein tau in serum/plasma
- amyloid-beta peptide 40/42 in plasma
References
- ↑ 1.0 1.1 1.2 George J Alzheimer's Blood Test More Accurate Than Primary Care or Specialist Diagnoses. Testing recommended only for patients with cognitive impairment, not the "worried well" MedPage Today, July 28, 2024 https://www.medpagetoday.com/meetingcoverage/aaic/111274
Palmqvist S, Tideman P, Mattsson-Carlgren N et al Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care. JAMA. 2024 Jul 28:e2413855. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39068545 https://jamanetwork.com/journals/jama/fullarticle/2821669 - ↑ 2.0 2.1 Monane M, Maraganore DM, Carlile RM et al Clinical Utility of an Alzheimer's Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study. Diagnostics (Basel). 2025 Jan 13;15(2):167. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39857051 PMCID: PMC11764142 Free PMC article. https://www.mdpi.com/2075-4418/15/2/167